My shortcut target looks like this:

"C:\Program Files (x86)\Notepad++\notepad++.exe" -multiInst

 

Taken from here.

Alt + Shift + Arrow keys. Taken from here.

 

HOW TO : Select column in Notepad++

 

“Alt + Left Mouse Click” puts you in Column Mode Select

From here.

 

Get precise and fine-tune your adjustments on the ruler by holding down the Alt key on your keyboard while you move things around. This will allow you to set very specific tabs and indents without having the "snap to" feature get in your way.

From here.