If the path to your PHP directory has spaces (e.g. "C:\Program Files\PHP") and IIS gives a 500+ error or responds with "The specified module could not be found." when you try to run a PHP script, try changing the ISAPI DLL's path in IIS (in the "Home Directory" tab, under "Configuration...") to the 8.3-equivalent path.
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That is, use C:\PROGRA~1\PHP\php5isapi.dll instead of "C:\Program Files\PHP\php5isapi.dll".
ĂÂ Copy/Pasted from here.